Fig. 1 · Structure
Documents & Downloads
DI-404
DCN1 Inhibitor
DI-404 is a potent inhibitor of DCN1, exhibiting a dissociation constant (Kd) of 6.7 nM. This compound selectively inhibits the neddylation of cullin 3 in a dose-dependent manner, making it a valuable tool for investigating cullin-RING ligase (CRL) pathways. Research applications include studying protein degradation mechanisms and exploring novel therapeutic strategies for diseases associated with dysregulated neddylation.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2187412-79-7 |
| Applications | DCN1 Inhibitor |
| Formula | C35H45ClN6O6S |
| Molecular Weight | 713.29 |
| SMILES | O=C(N[C@@H]1CCOC2=C1C=CC=C2)[C@@H](NC([C@@H](NC([C@@H](NC(CC)=O)CC3=NC4=CC=C(Cl)C=C4S3)=O)C5CCOCC5)=O)CCCCN |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.