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Diazaquinomycin A

Thymidylate Synthase Inhibitor

Diazaquinomycin A is a potent inhibitor of thymidylate synthase, a key enzyme involved in DNA synthesis. This diaza-anthracene antibiotic induces DNA damage and triggers cellular responses such as cell cycle arrest and apoptosis, evidenced by the cleavage of PARP. It serves as a valuable tool in cancer research and studies focused on therapeutic strategies targeting DNA replication and repair mechanisms.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	87614-40-2
Applications	Thymidylate Synthase Inhibitor
Formula	C₂₀H₂₂N₂O₄
Molecular Weight	354.40
SMILES	O=C1NC(C(C(N2)=C3C(CCC)=C(C)C2=O)=O)=C(C(CCC)=C1C)C3=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.