Fig. 1 · Structure
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DIBAC-GGFG-NH2CH2-Dxd
Linker-payload of Protein-drug Conjugates
DIBAC-GGFG-NH2CH2-Dxd functions as a linker-payload for protein-drug conjugates, specifically utilizing a Camptothecin derivative. It exhibits critical bioactivity as a payload for antibody-drug conjugates (ADCs), such as DS-8201a. The compound features a DBCO moiety, allowing it to participate in strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This unique reactivity makes it a valuable tool for targeted therapeutic applications in chemical biology and drug delivery systems.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2758875-01-1 |
| Applications | Linker-payload of Protein-drug Conjugates |
| Formula | C61H58FN9O12 |
| Molecular Weight | 1128.16 |
| SMILES | O=C(N1C2=CC=CC=C2C#CC3=CC=CC=C3C1)CCC(NCC(NCC(N[C@@H](CC4=CC=CC=C4)C(NCC(NCOCC(N[C@@H]5C6=C7C(C(N8C7)=CC([C@](O)(C(OC9)=O)CC)=C9C8=O)=NC%10=CC(F)=C(C)C(CC5)=C%106)=O)=O)=O)=O)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.