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Dimethylamiloride hydrochloride

NHE Inhibitor

Dimethylamiloride hydrochloride is a selective inhibitor of the Na+/H+ exchangers (NHE) with Ki values of 0.02, 0.25, and 14 μM for NHE1, NHE2, and NHE3, respectively. This reagent has significant implications in studies related to pain mechanisms and cellular ion regulation. Its ability to modulate intracellular pH makes it valuable for research applications exploring various physiological and pathophysiological processes.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2235-97-4
Applications	NHE Inhibitor
Formula	C₈H₁₃Cl₂N₇O
Molecular Weight	294.14
SMILES	O=C(C1=NC(Cl)=C(N(C)C)N=C1N)NC(N)=N.Cl

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.