Fig. 1 · Structure
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Diminazene
Antitrypanosomal Compound
Diminazene is an aromatic diamidine compound primarily targeting trypanosomiasis by inhibiting the replication of trypanosome parasites through its binding to kinetoplast DNA (kDNA). This compound exhibits key antitrypanosomal activity and is essential in researching treatments for this disease. Additionally, Diminazene demonstrates potential as an activator of angiotensin-converting enzyme 2 (ACE2) and may be explored for therapeutic applications in hypertension, rheumatoid arthritis, and immunomodulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 536-71-0 |
| Applications | Antitrypanosomal Compound |
| Formula | C14H15N7 |
| Molecular Weight | 281.32 |
| SMILES | N=C(C1=CC=C(C=C1)/N=N/NC2=CC=C(C(N)=N)C=C2)N |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.