Fig. 1 · Structure
Documents & Downloads
Direclidine
Muscarinic M4 Receptor PAM
Direclidine is a selective allosteric modulator of the muscarinic acetylcholine M4 receptor, known for its minimal affinity for M1, M2, M3, and M5 receptors. By non-covalently binding to the orthosteric site, Direclidine activates the M4 receptor, leading to the inhibition of acetylcholine release from striatal cholinergic interneurons. This mechanism helps to modulate the dopaminergic system and alleviate psychiatric symptoms linked to excessive dopamine activity. Direclidine is primarily utilized in research exploring neuropsychiatric disorders such as schizophrenia.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 1803346-98-6 |
| Applications | Muscarinic M4 Receptor PAM |
| Formula | C19H30N4O2 |
| Molecular Weight | 346.47 |
| Synonyms | NBI-1117568; HTL-0016878 |
| SMILES | CCOC(N1C[C@@]2(CC1)C[C@@H](N3CCC(C4=CC=NN4C)CC3)C2)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.