Fig. 1 · Structure
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DMT-5Me-dC(Bz)-CE Phosphoramidite
DNA Stabilizer
DMT-5Me-dC(Bz)-CE Phosphoramidite is a chemical building block designed for solid-phase DNA synthesis, targeting DNA stabilization. It enables the incorporation of 5-methylcytidine into oligonucleotide sequences, which enhances thermal stability and binding affinity. This phosphoramidite is particularly valuable for the synthesis of modified oligonucleotides, including locked nucleic acids (LNA), facilitating advancements in genetic research and therapeutic development.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 105931-57-5 |
| Applications | DNA Stabilizer |
| Formula | C47H54N5O8P |
| Molecular Weight | 847.93 |
| SMILES | CC(C)N(C(C)C)P(OCCC#N)O[C@@H](C[C@@](N1C(N=C(C(C)=C1)NC(C2=CC=CC=C2)=O)=O)([H])O3)[C@H]3COC(C4=CC=C(C=C4)OC)(C5=CC=CC=C5)C6=CC=C(C=C6)OC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.