DMX-5804

Catalog No.: A20199

MAP4K4 inhibitor

DMX-5804

DMX-5804 Chemical Structure

CAS NO. 2306178-56-1

DMX-5804 is a potent, orally active and selective MAP4K4 inhibitor, with an IC50 of 3 nM, a pIC50 of 8.55 for human MAP4K4, less potent on MINK1/MAP4K6 (pIC50, 8.18), and TNIK/MAP4K7 (pIC50, 7.96).

Availability: In stock

Package Price Qty
5 mg
$320.00
10 mg
$500.00
50 mg
$1,500.00
100 mg
$2,500.00
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Biological Activity

DMX-5804 is a potent, orally active and selective MAP4K4 inhibitor, with an IC50 of 3 nM, a pIC50 of 8.55 for human MAP4K4, less potent on MINK1/MAP4K6 (pIC50, 8.18), and TNIK/MAP4K7 (pIC50, 7.96).
In vitro DMSO 71 mg/mL (196.46 mM)
Water Insoluble
Ethanol 1 mg/mL (2.77 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.67 mL 138.35 mL 276.71 mL
0.5 mM 5.53 mL 27.67 mL 55.34 mL
1 mM 2.77 mL 13.84 mL 27.67 mL
5 mM 0.55 mL 2.77 mL 5.53 mL

*The above data is based on the productmolecular weight 361.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A20199
Actions Inhibitor
CAS No. 2306178-56-1
Formula C21H19N3O3
M. Wt 361.39
Solubility DMSO
Purity >98%
Synonyms DMX5804, DMX 5804
SMILES O=C1NC=NC2=C1C(C3=CC=C(OCCOC)C=C3)=CN2C4=CC=CC=C4
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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