Fig. 1 · Structure
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DNA crosslinker 4 dihydrochloride
DNA Minor Groove Binder
DNA Crosslinker 4 (dihydrochloride) is a potent DNA minor groove binder that selectively interacts with DNA strands, resulting in crosslinking. This compound exhibits significant inhibitory activity against cancer cell lines, including NCI-H460, A2780, and MCF-7. It serves as a valuable tool for anticancer research, facilitating investigations into DNA-targeted therapies and elucidating mechanisms of action in cancer biology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 2761734-23-8 |
| Applications | DNA Minor Groove Binder |
| Formula | C16H24Cl2N8O |
| Molecular Weight | 415.32 |
| SMILES | CC1=CC(N(N=C1CNC(N)=N)CC2=CC=C(C=C2)CNC(N)=N)=O.[H]Cl.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.