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ATM/ATR

ATM and ATR inhibitors act on ataxia telangiectasia mutated (ATM) and ATM and Rad3-related (ATR) kinases. The ATM gene was cloned in 1995 and encodes a protein similar to phosphatidylinositol 3-kinase (PI3K). ATR was cloned in 1996 as a candidate human cell cycle checkpoint protein. ATM responds mainly to DNA double-strand breaks, whereas ATR is activated by stalled replication forks. KU-55933, described in 2004 as a specific ATM inhibitor, is joined by KU-60019 and AZD0156. Ceralasertib, VE-821 and BAY-1895344 inhibit ATR and are used to study replication stress. Broader inhibitors of PI3K-related kinases, such as wortmannin, also appear in this list. Inhibitors of DNA-dependent protein kinase are listed in the sibling category DNA-PK.

1 Item

  • Chloroquine Phosphate
    Cat. No.
    A16445
    CAS No.
    50-63-5

    Chloroquine Phosphate

    Chloroquine phosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent, also acting as an ATM activator.

    In stock View Details
    100 mg
    $35.00
    250 mg
    $50.00
    All 3 sizes

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