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Topoisomerase

Topoisomerase inhibitors act on the enzymes that cut and rejoin DNA strands to relieve torsional stress. Type I topoisomerases cleave a single DNA strand, while type II enzymes pass one double helix through a transient break in another. Many inhibitors stabilize the cleavage complex, in which the enzyme remains covalently attached to broken DNA. Camptothecin traps topoisomerase I in this way and produces protein-linked DNA breaks. Irinotecan and its active metabolite SN 38 are camptothecin derivatives with the same target. Etoposide, doxorubicin and ellipticine inhibit topoisomerase II and are used in DNA damage and cell death research. Moxifloxacin, a fluoroquinolone antibacterial, represents the inhibitors of bacterial type II topoisomerases.

1 Item

  • TERT activator-2
    Cat. No.
    A57079
    CAS No.
    332939-29-4

    TERT activator-2

    TERT Activator-2 is a selective activator of telomerase reverse transcriptase (TERT), known to enhance the expression of TERT in cellular models. This compound is instrumental in studies focused on telomere maintenance and cellular lifespan, facilitating research into aging and age-related diseases. Its ability to modulate telomerase activity positions TERT Activator-2 as a valuable tool in the exploration of cellular senescence and regenerative medicine.

    In stock View Details
    25 mg
    $110.00
    50 mg
    $165.00
    All 5 sizes

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