Fig. 1 · Structure
Documents & Downloads
DNA relaxation-IN-1
DNA Ligase 1 Inhibitor
DNA relaxation-IN-1 is a selective inhibitor of DNA Ligase 1 (Lig1), a key enzyme involved in DNA ligation processes. By inhibiting Lig1, this compound disrupts DNA relaxation activity and promotes apoptosis in targeted cells. It demonstrates potential in enhancing therapeutic efficacy, particularly when used in combination with Topotecan, showing synergistic antiproliferative effects in colorectal cancer research.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2190506-29-5 |
| Applications | DNA Ligase 1 Inhibitor |
| Formula | C30H27N3O2S |
| Molecular Weight | 493.62 |
| SMILES | O=C(C1=CC=CS1)/C=C/C2=CC(C(C3=C(C)NC4=C3C=CC=C4)C(C#N)=C(N)O5)=C5C(C(C)(C)C)=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.