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DNDI-8219

Trypanocidal Agent

DNDI-8219 is a selective and orally active trypanocidal agent that demonstrates potent inhibitory activity against Trypanosoma cruzi, with an IC50 value of 0.4 μM. This compound exhibits low cytotoxicity, as evidenced by an IC50 greater than 100 μM in L6 cells. DNDI-8219 has been shown to effectively cure chronic T. cruzi infections and significantly reduce parasite burdens in mouse models. Its favorable solubility, metabolic stability, and safety profile further underscore its potential for research and therapeutic applications in treating Chagas disease.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	2222660-40-2
Applications	Trypanocidal Agent
Formula	C₁₃H₁₀F₃N₃O₅
Molecular Weight	345.23
SMILES	FC(F)(F)OC1=CC=C(O[C@@H]2CN3C(OC2)=NC([N+]([O-])=O)=C3)C=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.