Fig. 1 · Structure
Documents & Downloads
DOTA-bis(tert-butyl)ester
Bifunctional Chelator
DOTA-bis(tert-butyl)ester serves as a bifunctional chelator that facilitates the binding of radionuclides, making it essential for the preparation of radionuclide conjugates (RDCs). It can be conjugated with various salts to yield different metal chelators, such as DOTA-MN2, which can be radiolabeled with [67]Ga-citrate. In biological studies, [(67)Ga-DOTA-MN2] demonstrates stability in phosphate buffer solution and mouse plasma over a 24-hour period, exhibiting high tumor uptake and rapid plasma clearance in NFSa tumor models. This compound is a valuable tool for SPECT and PET imaging applications.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 913542-71-9 |
| Applications | Bifunctional Chelator |
| Formula | C24H44N4O8 |
| Molecular Weight | 516.63 |
| SMILES | O=C(OC(C)(C)C)CN1CCN(CC(O)=O)CCN(CC(OC(C)(C)C)=O)CCN(CC(O)=O)CC1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.