Chelators & Bifunctional Chelators

Cat. No.

A11103

CAS No.

85233-19-8

BAPTA

BAPTA is a selective calcium chelator.

Cat. No.

A11913

CAS No.

52-67-5

Penicillamine

Synonyms: D-(-)-Penicillamine

Penicillamine is a D-(-)-enantiomer of penicillamine that functions primarily as a heavy metal chelator. It facilitates the removal of excess copper and can influence oxidative stress levels. Additionally, it has implications for modulating immune responses and is investigated for its effects on seizure activity through nitric oxide and NMDA pathways. Penicillamine is utilized in research focused on Wilson's disease, rheumatoid arthritis, and cystinuria.

Cat. No.

A11980

CAS No.

16858-02-9

TPEN (TPEDA)

Synonyms: TPEDA

TPEN is a heavy metal chelator. Reacts with both Zn-proteome and Zn-metallothionein (MT) in LLC-PK1 cells; acts as an intracellular chelator of proteomic Zn2+.

Cat. No.

A14113

CAS No.

174267-71-1

DTPA-tetra (t-Bu ester)

Synonyms: tetra-tBu-DTPA

DTPA-tetra (t-Bu ester) is a bifunctional chelator designed for tumor pre-targeting applications. As a macrocyclic DTPA derivative, it facilitates the conjugation of peptides and radionuclides, enhancing the specificity and efficacy of targeted therapies. This reagent is particularly valuable in radiolabeling and drug development studies within cancer research.

Cat. No.

A17093

CAS No.

304-55-2

Succimer

Synonyms: DMSA

Succimer is an orally active heavy metal chelator.

Cat. No.

A17971

CAS No.

62-33-9

EDTA Calcium disodium,98%

Synonyms: EDTA calcium disodium salt; 98%; Adsorbonac

EDTA Calcium disodium is a highly effective chelating agent specifically designed to bind calcium and other metal ions, thereby inhibiting their involvement in chemical reactions. With a purity of 98%, it is commonly employed as a stain agent in SDS-PAGE to prevent metal ion interference in electrophoretic processes. This reagent is essential for maintaining the integrity of biological samples in various research applications.

Cat. No.

A20890

CAS No.

430462-93-4

HQ-415

HQ-415 is a class of clinically relevant bioactive metal chelators related to clioquinol. The effective concentration eliciting a EC50 for HQ-415 is 15 μM.

Cat. No.

A26851

CAS No.

945635-15-4

Deferitazole

Synonyms: FBS 0701

Deferitazole is an orally active iron chelator primarily targeting iron metabolism in parasites. Exhibiting significant antimalarial activity, it holds promise for the study and treatment of malaria. This compound serves as a valuable tool for researchers investigating the role of iron in the pathophysiology of malaria and exploring potential therapeutic strategies.

Cat. No.

A26888

CAS No.

312611-92-0

VK-28

VK-28 is a brain-permeable iron chelator that effectively inhibits both basal and Fe/ascorbate-induced mitochondrial membrane lipid peroxidation, exhibiting an IC50 of 12.7 μM. This compound demonstrates significant neuroprotective effects in the ICV-6-OHDA model. VK-28 is valuable for research focused on Parkinson’s disease and other neurodegenerative disorders.

Cat. No.

A26970

CAS No.

1335282-05-7

CN128 hydrochloride

Synonyms: CN328

CN128 hydrochloride is a selective iron chelator that exhibits oral bioavailability. This compound is primarily used in research related to β-thalassemia, facilitating studies on iron metabolism and its implications in hematological disorders. Its ability to effectively bind iron makes it a valuable tool for exploring therapeutic strategies in iron-overload conditions.

Cat. No.

A26985

CAS No.

35998-29-9

HBED

HBED is an effective iron chelator that specifically binds to ferric ions, facilitating their removal from biological systems. This compound is instrumental in research related to transfusion-related iron overload, providing insights into its underlying mechanisms and potential therapeutic strategies. Its ability to regulate iron homeostasis makes HBED a valuable tool for studying diseases associated with dysregulated iron metabolism.

Cat. No.

A28538

CAS No.

957-86-8

Pulcherriminic acid

Pulcherriminic acid is a cyclic dipeptide known for its iron-chelating properties. By forming the extracellular red pigment pulcherrimin through non-enzymatic chelation of Fe3+ ions, it effectively competes for iron availability, imparting significant antibacterial activity. This compound has notable applications across various fields, including food preservation, agricultural enhancement, and medical research.

Cat. No.

A28764

CAS No.

1407166-70-4

NODAGA-NHS

Synonyms: NODA-GA-NHS ester

NODAGA-NHS is an activated ester of the NODAGA chelator, designed for targeted radiolabeling applications. It facilitates the conjugation of Trastuzumab to form NODAGA-Trastuzumab, enabling the chelation of 64Cu for radiotracer development. This compound is particularly valuable in PET imaging studies of tumors expressing the HER2 receptor, making it a crucial tool in research related to HER2-positive breast cancer and ovarian adenocarcinoma.

Cat. No.

A28910

CAS No.

1583289-85-3

p-SCN-Bn-NOTA trihydrochloride

p-SCN-Bn-NOTA trihydrochloride is a macrocyclic chelator that forms stable complexes with metal ions, particularly suitable for radiolabeling applications. It can be covalently attached to peptides via the thiocyanate group, facilitating the formation of hexacoordinate copper complexes, such as with 64Cu. This compound binds selectively to GRPR and EGFR, which are overexpressed in various tumor cells, thereby enhancing the targeting of radioactive probes in tumor imaging and therapeutics. It is applicable in research focused on malignant tumors, including prostate and colorectal cancers.

Cat. No.

A30070

CAS No.

149-45-1

Tiron

Tiron is a non-toxic metal chelator that effectively binds various metal ions. As a cell-permeable analog of vitamin E, Tiron functions as a hydroxyl radical and superoxide scavenger, exhibiting antioxidant properties. It is suitable for research applications aimed at alleviating acute metal overload in biological systems, particularly in animal models.

Cat. No.

A37696

CAS No.

25102-12-9

EDTA dipotassium dihydrate

Synonyms: Ethylenediaminetetraacetic acid dipotassium dihydrate

EDTA dipotassium dihydrate is a versatile metal ion chelator that efficiently forms stable, water-soluble complexes with various metal ions. It is widely used as a blood anticoagulant to prevent coagulation, thereby preserving the morphology and functionality of cells in blood specimens. Additionally, in industrial applications, EDTA dipotassium dihydrate mitigates the detrimental effects of metal ions, helping to prevent oxidation and degradation processes.

Cat. No.

A38980

CAS No.

79514-41-3

ZMC3

Synonyms: NSC328784

ZMC3 (NSC328784) is a potent zinc chelator that effectively modulates zinc availability within cells. This compound exhibits metallochaperone properties and enhances sensitivity in p53-R175H mutant cells, making it a valuable tool for studying cancer biology. Additionally, ZMC3 has been shown to increase reactive oxygen species (ROS) levels, contributing to its role in cellular stress responses and potential therapeutic applications in oncological research.

Cat. No.

A39143

CAS No.

142609-62-9

MiADMSA

Synonyms: Monoisoamyl meso-2,3-dimercaptosuccinic acid

MiADMSA (Monoisoamyl meso-2,3-dimercaptosuccinic acid) is an oral thiol chelator effective in the removal of heavy metals, notably arsenic and lead, from biological systems. It operates by binding to these metals through its vicinal sulfhydryl groups, resulting in significant reductions in body metal burden and various oxidative stress markers, including reactive oxygen species and antioxidant enzymes. Research applications include the study of urinary bladder carcinogenesis, oxidative stress mitigation, and developmental neurotoxicity induced by heavy metals. MiADMSA demonstrates safety in animal models while providing protective effects against copper-induced histopathology and neurotoxicity.

Cat. No.

A41610

CAS No.

137076-54-1

DOTA-tri(t-butyl ester)

DOTA-tri(t-butyl ester) is a DOTA-like chelating agent that serves as a crucial precursor for the synthesis of nanospherical magnetic resonance imaging (MRI) contrast agents. This compound facilitates the enhancement of MR angiography and imaging of tumor angiogenesis, thereby playing an essential role in biomedical research and diagnostic applications. Its unique properties make it valuable for developing advanced imaging techniques in the study of vascular and oncological processes.

Cat. No.

A41613

CAS No.

1222468-90-7

p-SCN-Bn-deferoxamine

P-SCN-Bn-deferoxamine is a bifunctional chelating agent specifically designed to coordinate with radioactive metal nuclides, such as Zr-89, and biological targeting molecules, including antibodies. Its primary mechanism allows for the effective labeling of antibodies for immuno-PET imaging applications. This reagent is valuable for research in cancer diagnostics and targeted imaging studies.

Cat. No.

A41615

CAS No.

127985-74-4

p-SCN-Bn-DOTA

p-SCN-Bn-DOTA is a bifunctional chelating agent that effectively forms stable complexes with radionuclides while facilitating the conjugation of monoclonal antibodies. This compound is instrumental in radioimmunoassays for tumor targeting and imaging, enhancing the efficacy of radiolabeled antibodies in cancer research. Its unique chemical properties make it a valuable tool for the development of targeted radiotherapeutics and diagnostic agents.

Cat. No.

A41616

CAS No.

60239-18-1

Tetraxetan

Synonyms: DOTA

Tetraxetan (DOTA) is a macrocyclic chelating agent that effectively forms stable coordination complexes with various metal ions, including 68Ga, 111In, and 177Lu. Its ability to conjugate with targeting molecules, such as RGD peptides and folic acid, allows for directed targeting of specific biomolecules or cells. Tetraxetan is particularly useful in imaging studies of tumors, including melanoma and cancers that express folate receptors, such as cervical cancer.

Cat. No.

A41617

CAS No.

1295584-83-6

Maleimide-NOTA

Maleimide-NOTA is a versatile chelator specifically designed for the labeling of peptides and antibodies. This compound facilitates the conjugation of molecules by reacting with thiol groups in cysteine residues, enabling site-specific labeling and tracking of biomolecules. Maleimide-NOTA is particularly useful in bioconjugation techniques, enhancing the development of targeted therapeutics and diagnostics in chemical biology research.

Cat. No.

A41620

CAS No.

1375475-53-8

DOTAGA-anhydride

DOTAGA-anhydride is a bifunctional chelator based on the DOTA framework that effectively binds to radionuclides, facilitating the development of radionuclide drug conjugates (RDCs). This reagent has been successfully employed in the labeling of antibodies, such as Trastuzumab, enhancing their imaging capabilities. Additionally, DOTAGA-anhydride is valuable for synthesizing bimodal tags for applications in single-photon emission computed tomography (SPECT) and PET/optical imaging.

Cat. No.

A41621

CAS No.

56491-86-2

NOTA

NOTA is a bifunctional chelate that serves as a fundamental framework for the development of positron emission tomography (PET) imaging agents. It facilitates probe design and enhances signal amplification through multivalent interactions. NOTA is applicable in research related to multiple myeloma, breast cancer, lymphoma, and myocardial infarction, making it an essential tool in the field of cancer and cardiovascular studies.