Fig. 1 · Structure
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DOTA-GA-maleimide
Bifunctional Chelator
DOTA-GA-maleimide is a bifunctional chelator that facilitates both protein conjugation and radiometal chelation. It forms stable complexes with indium-111 (111In) and utilizes maleimide chemistry for protein conjugation. This reagent enables the radiolabeling of LFn, which can be applied in imaging studies of matrix metalloproteinase (MMP) activity. DOTA-GA-maleimide is particularly useful in cancer research, offering valuable insights into tumor biology and therapeutic responses.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1800229-46-2 |
| Applications | Bifunctional Chelator |
| Formula | C25H38N6O11 |
| Molecular Weight | 598.60 |
| SMILES | O=C(CN1CCN(CCN(C(CCC(NCCN2C(C=CC2=O)=O)=O)C(O)=O)CCN(CC1)CC(O)=O)CC(O)=O)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.