Fig. 1 · Structure
Documents & Downloads
DOTA-PEG5-azide
PROTAC Linkers
DOTA-PEG5-azide is a PEG-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAC) with alkyne-bearing molecules. Additionally, it is capable of participating in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized compounds. DOTA-PEG5-azide is instrumental in advancing research applications involving targeted protein degradation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 3104986-47-9 |
| Applications | PROTAC Linkers |
| Formula | C28H52N8O12 |
| Molecular Weight | 692.76 |
| SMILES | O=C(CN1CCN(CCN(CCN(CC1)CC(O)=O)CC(O)=O)CC(O)=O)NCCOCCOCCOCCOCCOCC[N-][N+]#N |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.