Fig. 1 · Structure
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DOTAGA-anhydride
Bifunctional Chelator
DOTAGA-anhydride is a bifunctional chelator based on the DOTA framework that effectively binds to radionuclides, facilitating the development of radionuclide drug conjugates (RDCs). This reagent has been successfully employed in the labeling of antibodies, such as Trastuzumab, enhancing their imaging capabilities. Additionally, DOTAGA-anhydride is valuable for synthesizing bimodal tags for applications in single-photon emission computed tomography (SPECT) and PET/optical imaging.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1375475-53-8 |
| Applications | Bifunctional Chelator |
| Formula | C19H30N4O9 |
| Molecular Weight | 458.46 |
| SMILES | O=C(O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(C(CCC(O2)=O)C2=O)CC1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.