Fig. 1 · Structure
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DOV-216,303
Serotonin Transporter Inhibitor
DOV-216,303 is a serotonin transporter inhibitor that effectively blocks the reuptake of norepinephrine, serotonin, and dopamine, exhibiting IC50 values of 14 nM, 20 nM, and 78 nM for hSERT, hNET, and hDAT, respectively. This compound has demonstrated the ability to enhance monoamine release in the prefrontal cortex of olfactory bulbectomized rats. DOV-216,303 is applicable in research focused on the mechanisms of antidepressants and the modulation of neurotransmitter systems.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 86215-36-3 |
| Applications | Serotonin Transporter Inhibitor |
| Formula | C11H12Cl3N |
| Molecular Weight | 264.58 |
| SMILES | ClC1=C(C=C(C23CC2CNC3)C=C1)Cl.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.