Fig. 1 · Structure
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Drofenine
Cholinesterase (ChE) Inhibitor
Drofenine is a potent competitive inhibitor of cholinesterase (ChE), with a Ki value of 3 μM. This compound effectively inhibits the breakdown of acetylcholine, leading to increased levels of this important neurotransmitter. Drofenine is utilized in research to study cholinergic signaling and its implications in neurodegenerative diseases, as well as to explore potential therapeutic avenues for conditions associated with impaired cholinergic transmission.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1679-76-1 |
| Applications | Cholinesterase (ChE) Inhibitor |
| Formula | C20H31NO2 |
| Molecular Weight | 317.47 |
| Synonyms | Cycloadiphene; Hexahydroadiphenine |
| SMILES | O=C(OCCN(CC)CC)C(C1CCCCC1)C2=CC=CC=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.