Fig. 1 · Structure
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DSM-421
Dihydroorotate dehydrogenase Inhibitor
DSM-421 is an orally active inhibitor of dihydroorotate dehydrogenase, an enzyme involved in pyrimidine biosynthesis. This compound exhibits significant antiplasmodium activity, making it a valuable tool for research on malaria and other parasitic diseases. Its mechanism of action presents important applications in developing therapeutic strategies targeting nucleotide synthesis in pathogenic organisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2011769-21-2 |
| Applications | Dihydroorotate dehydrogenase Inhibitor |
| Formula | C14H11F5N6 |
| Molecular Weight | 358.27 |
| SMILES | FC(F)(C1=NC=C(NC2=CC(C)=NC3=NC(C(F)(C)F)=NN32)C=C1)F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.