Fig. 1 · Structure
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DX3-213B
OXPHOS Complex I Inhibitor
DX3-213B is a potent inhibitor of oxidative phosphorylation (OXPHOS) complex I, with an IC50 of 3.6 nM. This compound effectively impairs ATP generation, exhibiting an IC50 of 11 nM, and demonstrates significant inhibition of MIA PaCa-2 cell growth, with a GI50 of 11 nM. DX3-213B is utilized in research focused on pancreatic cancer, providing valuable insights into metabolic targeting for therapeutic development.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2749555-66-4 |
| Applications | OXPHOS Complex I Inhibitor |
| Formula | C20H28F2N2O5S2 |
| Molecular Weight | 478.57 |
| SMILES | O=S(N1C[C@@H](CCC1)C(N2CCC(F)(CC2)F)=O)(C3=CC=C(C=C3)S(C(C)C)(=O)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.