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DY-9760e

Calmodulin Inhibitor

DY-9760e is a selective calmodulin (CaM) inhibitor that disrupts the Ca²⁺/CaM complex, thereby inhibiting various calmodulin-dependent enzymes, including nNOS, CaM kinase II, and calcineurin (Ki values of 0.9, 1.4, and 2.0 μM, respectively). This compound effectively inhibits excessive nitric oxide production and protein tyrosine nitration, while also preventing the activation of calpain and caspase-3. DY-9760e has demonstrated potential in reducing infarct size, enhancing cardiac function, and mitigating oxidative stress and cell death, making it a valuable tool in research related to myocardial infarction, cerebral ischemia, and other related disorders.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	179185-73-0
Applications	Calmodulin Inhibitor
Formula	C₂₆H₃₁ClN₆O₂.2ClH.7/2H₂O
Molecular Weight	630.50
SMILES	ClC1=CC=CC(N2CCN(CC2)CCC3=NN(CC4=CN=CN4)C5=C3C=C(OC)C(OC)=C5)=C1C.Cl.[7/2H2O].Cl

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.