Dyrk1A-IN-2

Catalog No.: A35105
DYRK1A Inhibitor
Dyrk1A-IN-2 is a potent DYRK1A inhibitor with an EC50 of 37 nM. This compound demonstrates significant capacity to promote human β-cell replication while exhibiting low cytotoxicity. Dyrk1A-IN-2 is a valuable tool for research in diabetes and regenerative medicine, aiding in the investigation of β-cell proliferation and function.
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5mg
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50mg
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionDyrk1A-IN-2 is a potent DYRK1A inhibitor with an EC50 of 37 nM. This compound demonstrates significant capacity to promote human β-cell replication while exhibiting low cytotoxicity. Dyrk1A-IN-2 is a valuable tool for research in diabetes and regenerative medicine, aiding in the investigation of β-cell proliferation and function.
Product Information
Catalog NumA35105
FormulaC27H34N6O3
Molecular Weight490.60
CAS Number2459657-37-3
SMILESCCOC(C1=C(C2=NC(C3=CC(N)=NC=C3)=CC=C2N=C1)N[C@@H]4CC[C@H](CC4)CN5CCOCC5)=O
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