Fig. 1 · Structure
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DZD1516
HER2 Inhibitor
DZD1516 is a highly potent and selective inhibitor of the HER2 receptor, exhibiting an IC50 value of 0.56 nM. This compound demonstrates significant antitumor activity in both central nervous system and subcutaneous xenograft mouse models, making it a valuable tool for research in cancer therapeutics targeting HER2-positive tumors. Its favorable blood-brain permeability further enhances its potential utility in investigating CNS-related malignancies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2387570-00-3 |
| Applications | HER2 Inhibitor |
| Formula | C28H27F2N7O3 |
| Molecular Weight | 547.56 |
| SMILES | COC1=CC2=C(C(NC3=CC=C(C(C)=C3)OC4=CC5=NC=NN5C=C4)=NC=N2)C(O[C@H]6CCN(CC6(F)F)C)=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.