Fig. 1 · Structure
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(E)-5-(2-Bromovinyl)pyrimidine-2,4(1H,3H)-dione
DNA/RNA Synthesi Inhibitor
(E)-5-(2-Bromovinyl)pyrimidine-2,4(1H,3H)-dione acts primarily as a DNA/RNA synthesis inhibitor by irreversibly inactivating dihydropyrimidine dehydrogenase (DPD) in an NADPH-dependent manner. This compound serves as an inactive metabolite of the antiviral drugs sorivudine and (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU), which can be regenerated in vivo. Research indicates that (E)-5-(2-Bromovinyl)pyrimidine-2,4(1H,3H)-dione enhances the antitumor efficacy of 5-fluorouracil in P388 murine leukemia models, leading to increased survival time, making it a valuable tool in cancer research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 69304-49-0 |
| Applications | DNA/RNA Synthesi Inhibitor |
| Formula | C6H5BrN2O2 |
| Molecular Weight | 217.02 |
| Synonyms | (E)-5-(2-Bromovinyl)uracil; BVU |
| SMILES | O=C1NC(C(/C=C/Br)=CN1)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.