Fig. 1 · Structure
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(E)-N-(3-Methoxyphenyl)cinnamamide
MMP-2/MMP-9 Inhibitor
(E)-N-(3-Methoxyphenyl)cinnamamide primarily targets the metalloproteinases MMP-2 and MMP-9, acting as a weakly selective inhibitor. It demonstrates inhibitory activity with IC50 values of 1674.81 nM for hMMP-2 and 1658.63 nM for hMMP-9, showing limited selectivity for MMP-1. This compound is relevant for cancer research, particularly in studies investigating tumor invasion and metastasis mediated by matrix metalloproteinases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 127033-74-3 |
| Applications | MMP-2/MMP-9 Inhibitor |
| Formula | C16H15NO2 |
| Molecular Weight | 253.30 |
| SMILES | N(C(/C=C/C1=CC=CC=C1)=O)C2=CC(OC)=CC=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.