Fig. 1 · Structure
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(E/Z)-Icerguastat hydrochloride
PPP1R15A Inhibitor
(E/Z)-Icerguastat hydrochloride is a selective inhibitor of PPP1R15A, which prolongs the phosphorylation of eIF2α. This compound plays a crucial role in protecting cells from proteostasis defects, highlighting its potential in cellular resilience. In preclinical studies, (E/Z)-Icerguastat hydrochloride demonstrated significant improvements in survival rates in prion-infected mouse models and effectively reduced PrPSc expression and prion activity in various neuronal cell lines persistently infected with different prion strains, making it a valuable tool for prion disease research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 32597-86-7 |
| Applications | PPP1R15A Inhibitor |
| Formula | C8H10Cl2N4 |
| Molecular Weight | 233.10 |
| Synonyms | (E/Z)-Sephin1 hydrochloride; (E/Z)-IFB-088 hydrochloride |
| SMILES | ClC1=CC=CC=C1/C=N/NC(N)=N.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.