Fig. 1 · Structure
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(E/Z)-Icerguastat
PPP1R15A Inhibitor
(E/Z)-Icerguastat is a selective inhibitor of the phosphatase regulatory subunit PPP1R15A (R15A). It exhibits significant activity in modulating protein phosphatase signaling pathways, making it a valuable tool for studying protein misfolding diseases. This compound is instrumental in research aimed at understanding the biochemical mechanisms underlying various neurodegenerative disorders and cellular stress responses.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 13098-73-2 |
| Applications | PPP1R15A Inhibitor |
| Formula | C8H9ClN4 |
| Molecular Weight | 196.64 |
| Synonyms | (E/Z)-Sephin1; (E/Z)-IFB-088 |
| SMILES | ClC1=CC=CC=C1/C=N/NC(N)=N |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.