Fig. 1 · Structure

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(E),(Z)-RNF5 agonist 1

RNF5 Agonist

(E),(Z)-RNF5 Agonist 1 is a potent RNF5 agonist that enhances the ubiquitination and degradation of the SARS-CoV-2 E protein. This compound effectively inhibits SARS-CoV-2 replication and reduces pulmonary pathology and systemic inflammation in mouse models of infection. Additionally, (E),(Z)-RNF5 Agonist 1 exhibits significant cytotoxicity against neuroblastoma and melanoma cell lines. It serves as a valuable tool for research in anti-cancer and antiviral therapeutic applications.

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Specifications

Manufacturer Adooq Bioscience
Actions Agonist
CAS Number 2231731-82-9
Applications RNF5 Agonist
Formula C22H18N4S
Molecular Weight 370.47
SMILES
CC1=NS/C(N1C2=CC=CC=C2)=N\C(C3=CC=CC=C3)=N\C4=CC=CC=C4

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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