Fig. 1 · Structure
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E6 Berbamine
Calmodulin Antagonist
E6 Berbamine is a potent calmodulin (CaM) antagonist that effectively inhibits calmodulin-dependent myosin light chain kinase (MLCK) with a Ki of 0.95 μM. This compound exhibits significant anti-leukemia activity, demonstrating an IC50 value of 2.13 μM in K562 cells. E6 Berbamine serves as a valuable tool in cancer research and studies targeting CaM signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 114784-59-7 |
| Applications | Calmodulin Antagonist |
| Formula | C44H43N3O9 |
| Molecular Weight | 757.83 |
| Synonyms | Berbamine p-nitrobenzoate |
| SMILES | COC1=C(OC2=CC3=C(C=C2OC)CCN4C)C5=C(C=C1OC)CCN(C)[C@@]5(CC6=CC=C(C(OC7=CC=C(C=C7)C[C@@]34[H])=C6)OC(C8=CC=C(C=C8)[N+]([O-])=O)=O)[H] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.