Fig. 1 · Structure
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Ebsulfur
Trypanothione Reductase Inhibitor
Ebsulfur is a benzisothiazolone compound that serves as a potent inhibitor of trypanothione reductase (TryR) in Trypanosoma brucei, exhibiting IC50 values ranging from 61 to 293 nM. This compound demonstrates significant cytocidal activity against the parasite and is valuable for research focused on African trypanosomiasis. Ebsulfur's mechanism of action and efficacy make it an important tool for studying diseases caused by this pathogenic organism.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2527-03-9 |
| Applications | Trypanothione Reductase Inhibitor |
| Formula | C13H9NOS |
| Molecular Weight | 227.28 |
| SMILES | O=C1N(C2=CC=CC=C2)SC3=C1C=CC=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.