• Sign In
  • FAQ
  • Create an Account
Currency
USD currency flagUSD
Toggle Nav
My Cart
Menu
Account
Settings
Currency
USD currency flagUSD

EG00229

Catalog No.: A34827
VEGF-A Inhibitor
EG00229 is a specific inhibitor of the VEGF-A and neuropilin-1 (NRP1) interaction, demonstrating an IC50 of 8 μM. This compound effectively inhibits the migration of human umbilical vein endothelial cells (HUVECs) and reduces the phosphorylation of VEGF receptor 2 (VEGFR2) in endothelial cells. Additionally, EG00229 shows cytotoxic effects in the A549 cancer cell line, making it a valuable tool for research in cancer biology and angiogenesis.
EG00229 1018927-63-3 VEGF-A Inhibitor
Grouped product items
Size Stock
5mg
10mg
50mg
Bulk Size
Bulk Discount
Bulk Inquiry
Notify me when the price drops
Notify me when this product is in stock
Free Delivery on orders over $500
Research use only. We do not sell to patients.
Data Sheet SDS

Loading distributor info...

Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionEG00229 is a specific inhibitor of the VEGF-A and neuropilin-1 (NRP1) interaction, demonstrating an IC50 of 8 μM. This compound effectively inhibits the migration of human umbilical vein endothelial cells (HUVECs) and reduces the phosphorylation of VEGF receptor 2 (VEGFR2) in endothelial cells. Additionally, EG00229 shows cytotoxic effects in the A549 cancer cell line, making it a valuable tool for research in cancer biology and angiogenesis.
Product Information
Catalog NumA34827
FormulaC17H19N7O5S3
Molecular Weight497.57
CAS Number1018927-63-3
SMILESN=C(N)NCCC[C@@H](C(O)=O)NC(C1=C(NS(=O)(C2=CC=CC3=NSN=C32)=O)C=CS1)=O
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass

    Concentration

    Volume

    Molecular Weight

Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

  • C1

    V1

    C2

    V2