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Biological Activity
EG00229 is the first small molecule inhibitors of the neuropilin-1 and VEGF-A interaction with an IC50 of inhibition of 8 uM(125I-VEGF binding to PAE/NRP1 cells).
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 16.35 mL | 81.75 mL | 163.51 mL |
| 0.5 mM | 3.27 mL | 16.35 mL | 32.7 mL |
| 1 mM | 1.64 mL | 8.18 mL | 16.35 mL |
| 5 mM | 0.33 mL | 1.64 mL | 3.27 mL |
*The above data is based on the productmolecular weight 611.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A16237 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1210945-69-9 |
| Formula | C19H20F3N7O7S3 |
| M. Wt | 611.6 |
| Purity | >98% |
| Synonyms | EG 00229, EG-00229 |
| SMILES | C1=CC2=NSN=C2C(=C1)S(=O)(=O)NC3=C(SC=C3)C(=O)NC(CCCN=C(N)N)C(=O)O.C(=O)(C(F)(F)F)O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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