EN1033 is a covalent molecular glue degrader targeting immune regulatory transcription factors IRF5 and IRF8. It induces proteasome-dependent degradation of IRF5 and demonstrates a more rapid and robust degradation of IRF8. By covalently modifying specific residues, EN1033 destabilizes these factors, leading to a reduction in their pro-inflammatory transcriptional activity. This reagent is valuable for exploring mechanisms in autoimmune and inflammatory disorders.
EN1033 is a covalent molecular glue degrader targeting immune regulatory transcription factors IRF5 and IRF8. It induces proteasome-dependent degradation of IRF5 and demonstrates a more rapid and robust degradation of IRF8. By covalently modifying specific residues, EN1033 destabilizes these factors, leading to a reduction in their pro-inflammatory transcriptional activity. This reagent is valuable for exploring mechanisms in autoimmune and inflammatory disorders.
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