Fig. 1 · Structure
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EP2 receptor antagonist-3
EP2 Receptor Antagonist
EP2 receptor antagonist-3 is a selective antagonist of the EP2 receptor, exhibiting an IC50 of 8 nM in human EP2 SPA assays and 50 nM in human EP2 cAMP assays. It enhances macrophage-mediated clearance of Amyloid-β plaques, making it a valuable tool for research into Alzheimer's disease and related neurodegenerative disorders. This compound can aid in understanding the role of EP2 receptors in immune response and amyloid pathology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1799626-16-6 |
| Applications | EP2 Receptor Antagonist |
| Formula | C23H19ClFN3O2 |
| Molecular Weight | 423.87 |
| SMILES | O=C1C=C(CN2CC3=CC(N4C=CC5=C4C=CC(F)=C5)=CC(Cl)=C3OCC2)C=CN1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.