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EP4 receptor antagonist 8

EP4 Antagonist

EP4 receptor antagonist 8 is a potent, orally active antagonist of the EP4 receptor, exhibiting an IC50 of 6.40 nM in human EP4 assays. This compound demonstrates significant efficacy in reducing paw and joint swelling, inflammatory cell infiltration, cartilage damage, pannus formation, and joint bone erosion in adjuvant-induced arthritis (AIA) mouse models, in a dose-dependent manner. EP4 receptor antagonist 8 serves as a valuable tool for the investigation of inflammatory pain mechanisms and therapeutic interventions.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	3068255-86-4
Applications	EP4 Antagonist
Formula	C₂₆H₂₁ClN₆O₄
Molecular Weight	516.94
SMILES	O=C(O)C1=CC=C(CNC(C2=C3C=CC=CC3=NN2CCNC(NC4=CC=C(C#N)C=C4Cl)=O)=O)C=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.