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Epaldeudomide

TNF-α Inhibitor

Epaldeudomide is a potent TNF-α inhibitor, demonstrating over 50% inhibition at a concentration of 100 nM. This compound effectively inhibits the proliferation of various cancer cell lines, including MM.1S with an IC50 of less than 300 nM, as well as WSU-DLCL-2 and Rec-1, both exhibiting IC50 values below 100 nM. Epaldeudomide is recognized for its antineoplastic properties, making it a valuable tool for cancer research and therapeutic studies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1918159-31-5
Applications	TNF-α Inhibitor
Formula	C₂₅H₂₅DFN₃O₅
Molecular Weight	468.50
SMILES	FC(C=C(C=C1)CN2CCOCC2)=C1COC3=C4C(C(N([C@]5([2H])C(NC(CC5)=O)=O)C4)=O)=CC=C3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.