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Epertinib

Catalog No.: A13777

EGFR/HER2/HER4 inhibitor

Epertinib

Epertinib Chemical Structure

CAS NO. 908305-13-5

Epertinib is a potent, oral, reversible, and selective tyrosine kinase inhibitor of EGFR, HER2 and HER4, with IC50s of 1.48 nM, 7.15 nM and 2.49 nM, respectively. Epertinib shows potent antitumor activity.

Availability: In stock

Package Price Qty
5 mg
$288.00
10 mg
$496.00
50 mg
$1,472.00
100 mg
$2,944.00
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Biological Activity

Epertinib is a potent, oral, reversible, and selective tyrosine kinase inhibitor of EGFR, HER2 and HER4, with IC50s of 1.48 nM, 7.15 nM and 2.49 nM, respectively. Epertinib shows potent antitumor activity.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.86 mL 89.28 mL 178.57 mL
0.5 mM 3.57 mL 17.86 mL 35.71 mL
1 mM 1.79 mL 8.93 mL 17.86 mL
5 mM 0.36 mL 1.79 mL 3.57 mL

*The above data is based on the productmolecular weight 560.02. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13777
Actions Inhibitor
CAS No. 908305-13-5
Formula C30H27ClFN5O3
M. Wt 560.02
Purity >98%
Synonyms S-22611, S22611, S 22611
SMILES CC#C/C(C1=CC2=C(NC3=CC=C(OCC4=CC=CC(F)=C4)C(Cl)=C3)N=CN=C2C=C1)=N\OC[[email protected]@H]5NCCOC5
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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