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Sirtuins

Sirtuin inhibitors and activators target the seven mammalian sirtuins, a family of protein deacetylases. Yeast silent information regulator 2 (Sir2), the founding member, is a histone deacetylase that requires nicotinamide adenine dinucleotide (NAD+). Human sirtuins (SIRT1 to SIRT7) differ in location, with SIRT1 mainly nuclear, SIRT2 mainly cytoplasmic and SIRT3 to SIRT5 in mitochondria. Selisistat, also known as EX-527, inhibits SIRT1, and SirReal2 selectively inhibits SIRT2. SRT1720 HCl and SRT2104 are described as synthetic SIRT1 activators. Nicotinamide, a product of the sirtuin reaction, inhibits sirtuin activity, while nicotinamide riboside is a precursor of NAD+.

2 Items

  • BF-175
    Cat. No.
    A32762
    CAS No.
    1333375-02-2

    BF-175

    BF-175 is a selective agonist of SIRT1, a protein involved in cellular regulation and energy metabolism. It enhances the activation of PGC1-α, promoting autophagy and apoptosis, while also inhibiting the activity of SREBP. BF-175 demonstrates protective effects against high glucose-induced mitochondrial damage and shows potential in attenuating the progression of diabetic kidney disease. Additionally, this compound has been investigated for its inhibitory effects on endometrial carcinoma, making it a valuable tool for research in metabolic and cancer studies.

    In stock View Details
    50 mg
    $350.00
    100 mg
    $545.00
    All 3 sizes
  • SKLB-11A
    Cat. No.
    A39444
    CAS No.
    433953-86-7

    SKLB-11A

    SKLB-11A is a selective, orally active allosteric agonist of SIRT3 (sirtuin 3), exhibiting a Kd value of 4.7 μM and demonstrating high selectivity for SIRT family members. This compound activates autophagy-related signaling pathways and plays a critical role in preventing mitochondrial dysfunction. SKLB-11A has shown efficacy in improving cardiac function in models of Doxorubicin-induced cardiotoxicity and myocardial ischemia/reperfusion, making it a valuable tool for research in cardiovascular protection and mitochondrial biology.

    In stock View Details
    5 mg
    $160.00
    10 mg
    $250.00
    All 5 sizes

2 Items

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