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Sirtuins

Sirtuin inhibitors and activators target the seven mammalian sirtuins, a family of protein deacetylases. Yeast silent information regulator 2 (Sir2), the founding member, is a histone deacetylase that requires nicotinamide adenine dinucleotide (NAD+). Human sirtuins (SIRT1 to SIRT7) differ in location, with SIRT1 mainly nuclear, SIRT2 mainly cytoplasmic and SIRT3 to SIRT5 in mitochondria. Selisistat, also known as EX-527, inhibits SIRT1, and SirReal2 selectively inhibits SIRT2. SRT1720 HCl and SRT2104 are described as synthetic SIRT1 activators. Nicotinamide, a product of the sirtuin reaction, inhibits sirtuin activity, while nicotinamide riboside is a precursor of NAD+.

2 Items

  • CrBKA
    Cat. No.
    A56988
    CAS No.
    2260810-48-6

    CrBKA

    CrBKA is a fluorogenic small-molecule substrate specifically designed for SIRT6, a member of the sirtuin family of NAD+-dependent deacetylases. This compound exhibits weak activity, making it suitable for probing SIRT6 enzymatic function in various biological contexts. Its application in research includes the study of cellular metabolism, aging, and the modulation of gene expression through deacetylation processes.

    In stock View Details
    5 mg
    $255.00
    10 mg
    $420.00
    All 5 sizes
  • Ac-QPKK(Ac)-AMC
    Cat. No.
    A57031
    CAS No.
    1387005-23-3

    Ac-QPKK(Ac)-AMC

    Ac-QPKK(Ac)-AMC is a fluorogenic substrate specifically designed for sirtuin enzymes, facilitating the study of sirtuin-mediated deacetylation processes. This reagent enables the quantitative analysis of sirtuin activity, making it a valuable tool for investigating the role of sirtuins in various biological processes and disease states, including aging and metabolic disorders. Researchers can leverage Ac-QPKK(Ac)-AMC to explore sirtuin function in high-throughput screening assays and in-depth mechanistic studies.

    In stock View Details
    1 mg
    $230.00
    5 mg
    $585.00
    All 2 sizes

2 Items

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