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Sirtuins

Sirtuin inhibitors and activators target the seven mammalian sirtuins, a family of protein deacetylases. Yeast silent information regulator 2 (Sir2), the founding member, is a histone deacetylase that requires nicotinamide adenine dinucleotide (NAD+). Human sirtuins (SIRT1 to SIRT7) differ in location, with SIRT1 mainly nuclear, SIRT2 mainly cytoplasmic and SIRT3 to SIRT5 in mitochondria. Selisistat, also known as EX-527, inhibits SIRT1, and SirReal2 selectively inhibits SIRT2. SRT1720 HCl and SRT2104 are described as synthetic SIRT1 activators. Nicotinamide, a product of the sirtuin reaction, inhibits sirtuin activity, while nicotinamide riboside is a precursor of NAD+.

4 Items

  • BF-175
    Cat. No.
    A32762
    CAS No.
    1333375-02-2

    BF-175

    BF-175 is a selective agonist of SIRT1, a protein involved in cellular regulation and energy metabolism. It enhances the activation of PGC1-α, promoting autophagy and apoptosis, while also inhibiting the activity of SREBP. BF-175 demonstrates protective effects against high glucose-induced mitochondrial damage and shows potential in attenuating the progression of diabetic kidney disease. Additionally, this compound has been investigated for its inhibitory effects on endometrial carcinoma, making it a valuable tool for research in metabolic and cancer studies.

    In stock View Details
    50 mg
    $350.00
    100 mg
    $545.00
    All 3 sizes
  • SKLB-11A
    Cat. No.
    A39444
    CAS No.
    433953-86-7

    SKLB-11A

    SKLB-11A is a selective, orally active allosteric agonist of SIRT3 (sirtuin 3), exhibiting a Kd value of 4.7 μM and demonstrating high selectivity for SIRT family members. This compound activates autophagy-related signaling pathways and plays a critical role in preventing mitochondrial dysfunction. SKLB-11A has shown efficacy in improving cardiac function in models of Doxorubicin-induced cardiotoxicity and myocardial ischemia/reperfusion, making it a valuable tool for research in cardiovascular protection and mitochondrial biology.

    In stock View Details
    5 mg
    $160.00
    10 mg
    $250.00
    All 5 sizes
  • CrBKA
    Cat. No.
    A56988
    CAS No.
    2260810-48-6

    CrBKA

    CrBKA is a fluorogenic small-molecule substrate specifically designed for SIRT6, a member of the sirtuin family of NAD+-dependent deacetylases. This compound exhibits weak activity, making it suitable for probing SIRT6 enzymatic function in various biological contexts. Its application in research includes the study of cellular metabolism, aging, and the modulation of gene expression through deacetylation processes.

    In stock View Details
    5 mg
    $255.00
    10 mg
    $420.00
    All 5 sizes
  • Ac-QPKK(Ac)-AMC
    Cat. No.
    A57031
    CAS No.
    1387005-23-3

    Ac-QPKK(Ac)-AMC

    Ac-QPKK(Ac)-AMC is a fluorogenic substrate specifically designed for sirtuin enzymes, facilitating the study of sirtuin-mediated deacetylation processes. This reagent enables the quantitative analysis of sirtuin activity, making it a valuable tool for investigating the role of sirtuins in various biological processes and disease states, including aging and metabolic disorders. Researchers can leverage Ac-QPKK(Ac)-AMC to explore sirtuin function in high-throughput screening assays and in-depth mechanistic studies.

    In stock View Details
    1 mg
    $230.00
    5 mg
    $585.00
    All 2 sizes

4 Items

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