Fig. 1 · Structure
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ER-Laurdan
Endoplasmic Reticulum Probe
ER-Laurdan is a specialized fluorescent probe targeting the endoplasmic reticulum (ER) with a high degree of membrane permeability. This derivative of Laurdan serves as a membrane fluidity reporter, localizing specifically to the ER luminal membrane and exhibiting a strong solvatochromic response to variations in membrane fluidity, influenced by membrane packing and saturated fatty acid stress. Its distinct localization allows for quantitative analysis of ER membrane fluidity through generalized polarization ratio measurements and facilitates the use of ER markers for automatic signal masking. ER-Laurdan is a crucial tool for studying metabolic disorders and elucidating alterations in the physical properties of cell membranes.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 3091879-77-2 |
| Applications | Endoplasmic Reticulum Probe |
| Formula | C54H80F5N3O13 |
| Molecular Weight | 1074.22 |
| SMILES | O=C(C1=C(F)C(F)=C(F)C(F)=C1F)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(CN(C)C2=CC=C3C(C=CC(C(CCCCCCCCCCC)=O)=C3)=C2)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.