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- Tomohiro Nabekura, .et al. Microtubule-targeting anticancer drug eribulin induces drug efflux transporter P-glycoprotein, Biochem Biophys Rep, 2020, Mar; 21: 100727 PMID: 31993509
- Snyder C, .et al. In vitro assessment of chemotherapy-induced neuronal toxicity, Toxicol In Vitro, 2018, Aug;50:109-123 PMID: 29427706
Biological Activity
Eribulin mesylate is the mesylate salt of a synthetic analogue of halichondrin B, a substance derived from a marine sponge (Lissodendoryx sp.) with antineoplastic activity.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 12.11 mL | 60.53 mL | 121.07 mL |
| 0.5 mM | 2.42 mL | 12.11 mL | 24.21 mL |
| 1 mM | 1.21 mL | 6.05 mL | 12.11 mL |
| 5 mM | 0.24 mL | 1.21 mL | 2.42 mL |
*The above data is based on the productmolecular weight 826. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A12804 |
|---|---|
| CAS No. | 441045-17-6 |
| Formula | C41H63NO14S |
| M. Wt | 826 |
| Purity | >98% |
| Synonyms | halichrondrin B analog, B1939, E7389, ER-086526,Halaven |
| SMILES | C[C@@H]1C[C@@H]2CC[C@H]3C(=C)C[C@@H](O3)CC[C@]45C[C@@H]6[C@H](O4)[C@H]7[C@@H](O6)[C@@H](O5)[C@@H]8[C@@H](O7)CC[C@@H](O8)CC(=O)C[C@H]9[C@H](C[C@H](C1=C)O2)O[C@@H]([C@@H]9OC)C[C@@H](CN)O.CS(=O)(=O)O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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