ERK-IN-4 is a selective extracellular signal-regulated kinase (ERK) inhibitor that preferentially binds to ERK2 with a dissociation constant (K_d) of 5 μM. It specifically inhibits the phosphorylation of downstream ERK substrates, including Rsk-1 and Elk-1, without significantly affecting the phosphorylation of ERK itself by its upstream activators MEK1/2. This targeted mode of action allows ERK-IN-4 to modulate ERK signaling output without disrupting upstream pathway dynamics, making it a useful tool for studying ERK-mediated cellular processes and potential therapeutic intervention in ERK-driven diseases.
ERK-IN-4 is a selective extracellular signal-regulated kinase (ERK) inhibitor that preferentially binds to ERK2 with a dissociation constant (K_d) of 5 μM. It specifically inhibits the phosphorylation of downstream ERK substrates, including Rsk-1 and Elk-1, without significantly affecting the phosphorylation of ERK itself by its upstream activators MEK1/2. This targeted mode of action allows ERK-IN-4 to modulate ERK signaling output without disrupting upstream pathway dynamics, making it a useful tool for studying ERK-mediated cellular processes and potential therapeutic intervention in ERK-driven diseases.
Product Information
Catalog Num
A24156
Formula
C14H17ClN2O3S
Molecular Weight
328.81
CAS Number
1049738-54-6
SMILES
O=C(N(CCN)C/1=O)SC1=C/C2=CC=C(OCC)C=C2.[H]Cl
Storage
Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
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