ErSO-TFPy is a selective activator of the TRPM4 ion channel, designed for studying its effects on calcium and sodium ion homeostasis in cells. This compound exhibits low nanomolar cytotoxicity specifically towards ERα+ breast cancer cells, leading to dysregulation of calcium balance and triggering an anticipatory unfolded protein response. The resultant cellular stress induces immune cell-independent necrotic cell death. ErSO-TFPy is a valuable tool for investigating the mechanisms underlying estrogen receptor alpha positive breast cancer.
ErSO-TFPy is a selective activator of the TRPM4 ion channel, designed for studying its effects on calcium and sodium ion homeostasis in cells. This compound exhibits low nanomolar cytotoxicity specifically towards ERα+ breast cancer cells, leading to dysregulation of calcium balance and triggering an anticipatory unfolded protein response. The resultant cellular stress induces immune cell-independent necrotic cell death. ErSO-TFPy is a valuable tool for investigating the mechanisms underlying estrogen receptor alpha positive breast cancer.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
