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Escholtzine

Catalog No.: A46095
Alkaloid
Escholtzine is an alkaloid derived from Eschscholzia californica, primarily known for its inhibitory effects on the 5-HT1A receptor, demonstrated by an EC50 value of 11 μM and a Ki of 6 μM. Additionally, it inhibits CYP3A4 with an IC50 of 13.4 μg/mL. This compound is valuable for research in neurological diseases, particularly in models related to anxiety.
Escholtzine 4040-75-9 Alkaloid
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionEscholtzine is an alkaloid derived from Eschscholzia californica, primarily known for its inhibitory effects on the 5-HT1A receptor, demonstrated by an EC50 value of 11 μM and a Ki of 6 μM. Additionally, it inhibits CYP3A4 with an IC50 of 13.4 μg/mL. This compound is valuable for research in neurological diseases, particularly in models related to anxiety.
Product Information
Catalog NumA46095
FormulaC19H17NO4
Molecular Weight323.34
CAS Number4040-75-9
SMILES[H][C@]1(N2C)CC3=CC4=C(OCO4)C=C3[C@]2([H])CC5=CC6=C(OCO6)C=C51
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