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ESI-05 (NSC 116966) is a specific antagonist of EPAC2 (exchange protein directly activated by cAMP 2), with an IC50 of 0.4 ?M. ESI-05 (NSC 116966) inhibits cAMP-mediated activation of EPAC2 as well as EAPC2 mediated Rap1 activation.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 36.45 mL | 182.24 mL | 364.47 mL |
| 0.5 mM | 7.29 mL | 36.45 mL | 72.89 mL |
| 1 mM | 3.64 mL | 18.22 mL | 36.45 mL |
| 5 mM | 0.73 mL | 3.64 mL | 7.29 mL |
*The above data is based on the productmolecular weight 274.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A18644 |
|---|---|
| Actions | Antagonist |
| CAS No. | 5184-64-5 |
| Formula | C16H18O2S |
| M. Wt | 274.37 |
| Purity | >98% |
| Synonyms | ESI05, ESI 05 |
| SMILES | O=S(C1=C(C)C=C(C)C=C1C)(C2=CC=C(C)C=C2)=O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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