Fig. 1 · Structure
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EST64454 hydrochloride
Sigma-1 Receptor Antagonist
EST64454 hydrochloride is a selective antagonist of the sigma-1 receptor, exhibiting a Ki value of 22 nM. This compound shows promise in the investigation of pain mechanisms and may facilitate new research into pain management therapies. Its oral bioavailability allows for convenient applications in preclinical studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1950569-11-5 |
| Applications | Sigma-1 Receptor Antagonist |
| Formula | C18H23ClF2N4O2 |
| Molecular Weight | 400.85 |
| SMILES | CC(N1CCN(CCOCC2=NN(C3=CC=C(F)C(F)=C3)C=C2)CC1)=O.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.