Fig. 1 · Structure
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Estradiol 17-(β-D-Glucuronide)
Metabolite of Estrogen
Estradiol 17-(β-D-Glucuronide) is a D-ring glucuronide metabolite of estrogen, primarily formed in the liver. This compound serves as a substrate for the organic anion-transporting polypeptide family (Oatp) and multidrug resistance-associated protein 2 (Mrp2), playing a crucial role in regulating MRP8-mediated transport processes. Additionally, it induces an immediate and reversible reduction in bile flow, leading to acute intrahepatic cholestasis in female rats, making it a valuable reagent for research in liver function and cholestatic disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Substrate |
| CAS Number | 1806-98-0 |
| Applications | Metabolite of Estrogen |
| Formula | C24H32O8 |
| Molecular Weight | 448.51 |
| SMILES | C[C@@]12[C@](CC[C@@H]2O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)C(O)=O)([H])[C@@]4([H])[C@@](CC1)([H])C5=CC=C(O)C=C5CC4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.