Fig. 1 · Structure
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Eticlopride hydrochloride
D2 Receptor Antagonist
Eticlopride hydrochloride is a selective antagonist of the dopamine D2 receptor, demonstrating high binding affinity for D2, α1-adrenergic, α2-adrenergic, and various serotonin receptors. This compound has KIs of 0.09 nM for D2, 112 nM for α1, 699 nM for α2, 6220 nM for 5HT1, and 830 nM for 5HT2. Eticlopride hydrochloride is primarily utilized in research related to antipsychotic mechanisms and dopamine signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 97612-24-3 |
| Applications | D2 Receptor Antagonist |
| Formula | C17H26Cl2N2O3 |
| Molecular Weight | 377.31 |
| SMILES | O=C(NC[C@H]1N(CC)CCC1)C2=C(O)C(CC)=CC(Cl)=C2OC.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.